CLL and MM may have different mechanisms of cell survival.

2003 AUG 25 - (NewsRx.com & NewsRx.net) -- CLL and MM may have different mechanisms of cell survival.

"We compared gene expression in purified tumor cells from untreated patients with chronic lymphocytic (CLL) (n=24) and newly diagnosed multiple myeloma (MM) (n=29) using the Affymetrix HuGeneFL microarray with probes for approximately 6800 genes," scientists in the United States report.

"Hierarchical clustering analysis showed that CLL and MM have distinct expression profiles (class prediction). Gene and protein expression (measured by flow cytometry) correlated well for CD19, CD20, CD23, and CD138 in CLL and MM, but not for immunoglobulin light chain, CD38 …